Abstract
How to Create Animal Models Using Genetic Knowledge?
Highlights
New animal models have emerged in recent years; some are based on the possibility of genetic modifications as close as possible to those found in humans
The creation of animal models using genetics is promising for creating drugs or treatments in diseases that are difficult to observe in animals
In just a few years, the progress made by molecular genetics has revolutionized the knowledge of neurodegenerative diseases: the neurologist was looking for a symptom [dementia, aphasia, cerebellar syndrome] that would one day enable him to better understand the mechanism of these affections
Summary
It has long been believed that there are natural patterns of human neurodegenerative diseases Numerous neurological phenotypes, such as those observed in the mouse lines Reeler, Weaver and Staggerer, presenting disorders of balance and gait, have been identified and selected in farm animals. The phenotypes of the natural models evoked those of the human affections, and this similarity suggested that the selected lines could be useful for the research of physiopathological mechanisms [9]. These were mostly false leads, and most predictions proved to be erroneous, demonstrating, once again, that phenotypic analogy does not mean mechanistic kinship
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
