Abstract
DNA from a genomic library of Leishmania amazonensis and from pcDNA3 plasmid were used to immunize BALB/c mice. Three immunizations at two weeks intervals were done, with 50jig/0. l ml of DNA. A control group was also injected with the same volume of satine solution. Afterward, ali mice were challenged with infective promastigotes of the parasite, and the development of lesions was followed during 16 weeks by dorsoventrai measures of the footpad. Mice previously immunized with the genomic library were capable of controlling lesions at a significant levei, with major significance between 9 and 13 weeks postchallenge.
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