Significance of sphincter of oddi dysfunction in the recurrence of choledocholithiasis after cholecystectomy

Abstract

Objective To explore the function of sphincter of oddi dysfunction (SOD) in the recurrence of choledocholithiasis after cholecystectomy. Methods Between June 2012 and June 2015, sixty-two cases were enrolled, with 24 of recurrent bile duct stones after cholecystectomy (recurrence group), 20 without gallbladder excision operation of common bile duct stones (control group), and 18 cases after cholecystectomy with residual stone (residual group). The direct biliary manometry including the sphincter Oddi basal pressure (SOBP), sphincter contraction amplitude (SOCA) and sphincter contraction frequency (SOF) were measured by ManoScan measuring system. Results The differences of SOBP and SOF among the three groups were statistically significant (F=8.584, 14.690, P=0.001, 0.001), while there was no significant difference among the three groups in SOCA (F=2.572, P=0.087). Compared to the control group and residual group, SOBP and SOF in the recurrence group were higher, with statistically significant difference (t=3.709, 2.998, P=0.001, 0.004; t=4.663, 4.167, both P<0.01). Conclusion The sphincter of oddi dysfunction plays a role in the recurrence of choledocholithiasis after cholecystectomy. Key words: Sphincter of oddi dysfunction; Choledocholithiasis; Recurrence; Biliary manometry