Significance of combined detection of serum SMRP and CA125 in the diagnosis of malignant peritoneal mesothelioma

Abstract

Objective To evaluate the values of combined detection of soluble mesothelin related proteins(SMRP) and carbohydrate antigen 125(CA125) in the diagnosis of malignant peritoneal mesothelioma. Methods 20 patients with malignant peritoneal mesothelioma were selected as the malignant group, 50 patients with benign ovarian tumor were selected as the benign group, 60 healthy women were selected as the control group.Enzyme-linked immunosorbent assay(ELISA) was adopted to detect serum SMRP levels and electrochemiluminescence immunifaction(ECLI) was adopted to detect serum CA125 levels.The SMRP, CA125 levels were compared among all groups, the sensitivity, specificity of SMRP and CA125 in the diagnosis of peritoneal malignant mesothelioma were analyzed. Results Serum levels of SMRP, CA125 in malignant group were (14.8±1.6)μg/L, (189.1±15.3)μg/L respectively, which were significantly higher than those in the benign group[(3.9±0.9)μg/L, (28.6±4.2)μg/L](t=27.40, 49.610, all P<0.01) and the control group[(2.8±0.7)μg/L, (16.9±3.8)μg/L](t=29.877, 53.334, all P<0.01).The sensitivities of SMRP, CA125 detection alone for malignant peritoneal mesothelioma diagnosis were 65.0%, 50%, respectively, while their specificities were 83.6%, 79.1%.The sensitivity and specificity of combined detection of SMRP and CA125 for malignant peritoneal mesothelioma were 95.0% and 93.6%. Conclusion SMRP has some value in the diagnosis of peritoneal malignant mesothelioma.SMRP combined with CA125 detection can markedly improve the diagnostic sensitivity and specificity for malignant peritoneal mesothelioma. Key words: Mesothelioma; Peritoneal neoplasms; Diagnosis