The effect of TVCDS and RI index combined with serum CA125 and CA199 levels detection on the diagnostic efficacy of ovarian cancer

Abstract

Objective To explore the effect of transvaginal color Doppler sonography (TVCDS) and Doppler ultrasound resistance index (RI index) combined with serum carbohydrate antigen 125 (CA125) and carbohydrate antigen 199 (CA199) levels detection on the diagnostic efficacy of ovarian cancer. Methods 44 patients with ovarian cancer (group A) and 38 patients with benign ovarian tumor (group B) in our hospital from January 2014 to February 2017 were selected, all cases were confirmed by the pathology. Another 40 healthy subjects were selected at the same period (group C). TVCDS examination was performed and serum levels of CA125 and CA199 were measured by chemiluminescence immunoassay. Serum CA125, CA199 levels in the three groups, TVCDS blood flow parameters [systolic peak flow velocity (PSV), end diastolic flow velocity (EDV), and RI index] in group A and B were compared. The sensitivity, specificity, accuracy, missed diagnosis rate, and misdiagnosis rate of TVCDS (RI), serum CA125 and CA199 levels separate and combined diagnosis of early ovarian cancer were analyzed. Results Single factor analysis of variance showed that the differences of serum CA125 and CA199 levels among the three groups were statistically significant (P<0.05). The serum levels of CA125 and CA199 in group A were significantly higher than those in group B and group C, with statistically significant differences (P<0.05). The PSV and EDV in group A were higher than those in group B, and RI was lower than that in group B, with statistically significant differences (P<0.05). The sensitivity of combined detection for early ovarian cancer was 93.18% (41/44), the specificity was 97.37% (37/38), the accuracy was 95.12% (78/82), which were higher than those of TVCDS (RI), serum CA125, CA199 levels separate detection, with statistically significant differences (P<0.05). The rate of missed diagnosis of combined detection was 6.82% (3/44), and the rate of misdiagnosis was 2.63% (1/38), which were lower than those of TVCDS (RI), serum CA125 and CA199 levels separate detection, with statistically significant differences (P<0.05). Conclusion TVCDS and RI index combined with serum CA125 and CA199 levels can detect early malignant tumor in patients with ovarian cancer, which has high diagnostic value, and can reduce the missed diagnosis and misdiagnosis, worthy of clinical application. Key words: TVCDS; RI index; CA125; CA199; Ovarian cancer; Diagnostic efficacy