Correlation analysis of serum HE4, CA125 and CA199 expression levels with ovarian cancer

Abstract

Objective To investigate the correlation between serum human epididymal protein 4 (HE4), carbohydrate antigen 125 (CA125) and carbohydrate antigen 199 (CA199) expression levels and ovarian cancer. Methods The clinical data of 106 patients with ovarian diseases admitted to the Fifth People’s Hospital of Datong from April 2016 to April 2018 were retrospectively collected. According to the pathological examination results, they were divided into benign ovarian tumor group (56 cases) and ovarian cancer group (50 cases). In addition, 68 healthy women who underwent physical examination during the same period were selected as control group. Fasting elbow venous blood was collected from all subjects in the morning, serum HE4, CA125 and CA199 levels were detected, and the correlation between serum HE4, CA125 and CA199 levels and ovarian cancer was evaluated. Results The serum levels of HE4, CA125 and CA199 in ovarian cancer group were higher than those in benign ovarian tumors group and control group, and the serum levels of HE4, CA125 and CA199 in benign ovarian tumors group were higher than those in control group, and the difference was statistically significant (P 0, P<0.05), that is, the risk of ovarian cancer increased with the increase of serum HE4, CA125 and CA199 levels. Conclusions Serum levels of HE4, CA125 and CA199 have important value in the diagnosis of ovarian cancer, and their expression levels are significantly positive correlated with ovarian cancer. Abnormal increase of serum HE4, CA125 and CA199 indicates an increased risk of ovarian cancer. Key words: Ovarian cancer; Human epididymal protein 4; Carbohydrate antigen 125; Carbohydrate antigen 199