Abstract
The objective of this article is to analyze the serum level of Prolactin (s-PRL) in 307 treated patients with Rheumatoid Arthritis (RA), and its association to disease activity, demographics, serological and clinical variables. The hypothesis to be tested: s-PRL correlates to disease activity in RA. Serum concentration of the hormone Prolactin (s-PRL) was determined in 307 treated patients with (RA) in a cross-sectional study design. The patients were characterized by demographic, serological and clinical variables, in addition to assessment of disease activity by DAS28 (3w-CRP) score. Prolactin was analyzed by a double sandwich immune analysis. Among the 307 RA-patients examined, only 4 patients had high s- PRL defined as females ＞ 637 mIU/L, and males ＞ 456 mIU/L. These 4 patients all had low disease activity score (DAS 28 score ＜ 2, 0). There was no correlation of s-PRL to DAS28 score (r= -0, 08, p=0.21), and no correlation of s-PRL to the number of swollen or tender joints, pain, CRP, Rheumatoid factor or anti-CCP. We demonstrated that 4 out of 307 RA patients had high level of s-PRL, all of them with low disease activity score. No correlation of s-PRL to disease activity DAS 28 score was demonstrated. We therefore question the hypothesis that PRL may play a role in disease severity and the development of rheumatoid arthritis.
Highlights
The hormone prolactin (PRL) is secreted from the pituitary gland and other organs and cells, lymphocytes
We demonstrated that 4 out of 307 Rheumatoid Arthritis (RA) patients had high level of Serum concentration of the hormone Prolactin (s-PRL), all of them with low disease activity score
There was no correlation of s-PRL to the number of swollen or tender joints, pain or CRP. It has been suggested by Chikanza I.Cet.al (1996) that excess prolactin levels may be of pathogenic importance in rheumatoid arthritis
Summary
The hormone prolactin (PRL) is secreted from the pituitary gland and other organs and cells, lymphocytes. Erythematosus (SLE), Rheumatoid Arthritis (RA), psoriasis, celiac disease, Sjögren’s syndrome , Hashimoto’s thyrioiditis and Systemic Sclerosis as reviewed by Shelly S et al (2012). It has been suggested by Chikanza I.C (1996) that excessive PRL secretion may be of pathogenic importance in RA. None of the present studies, have correlated s-PRL to modern disease activity scores such as DAS 28 commonly used in daily clinical practice and in research
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