Abstract
To evaluate the effects of alcohol consumption on disease activity in rheumatoid arthritis. EMBASE, Pubmed, the Cochrane Library, and Web of Science were searched until July 29, 2020. English language studies that reported disease activity outcomes in rheumatoid arthritis were included. Studies were excluded if they were reviews, case reports, had fewer than 20 patients, or reported on prevalence but not disease activity in RA. Forest plots were used to determine pooled mean difference and were generated on RevMan5.3. Linear regression was used to determine correlations between alcohol and antibody status, gender, and smoking status. The search identified 4126 citations of which 14 were included. The pooled mean difference in DAS28 (95% CI) was 0.34 (0.24, 0.44) (p < 10−5) between drinkers and non-drinkers with lower DAS28 in non-drinkers, 0.33 (0.05, 0.62) (p = 0.02) between heavy drinkers and non-drinkers with lower DAS28 in heavy drinkers, and 0.00 (− 0.30, 0.30) (p = 0.98) between low- and high-risk drinkers. The mean difference of HAQ assessments was significantly different between those who drink alcohol compared to those who do not, with drinkers reporting lower HAQ scores (0.3 (0.18, 0.41), p < 10−5). There was no significant correlation between drinking and gender, smoking status, or antibody positivity. Alcohol consumption is associated with lower disease activity and self-reported health assessment in rheumatoid arthritis. However, drinking has no correlation with smoking, gender, or antibody status.
Highlights
To evaluate the effects of alcohol consumption on disease activity in rheumatoid arthritis
This study presents a systematic review and a meta-analysis to evaluate the relationship between alcohol intake and disease activity in Rheumatoid Arthritis (RA)
Our systematic analysis supported a relationship between alcohol consumption and disease activity in RA, where disease activity and health assessment questionnaire (HAQ) scores are lower in those who consume alcohol compared to those who do not
Summary
To evaluate the effects of alcohol consumption on disease activity in rheumatoid arthritis. Alcohol consumption is associated with lower disease activity and self-reported health assessment in rheumatoid arthritis. Rheumatoid Arthritis (RA) is a chronic inflammatory condition which if left untreated can lead to joint inflammation, damage and a reduction in life expectancy[1,2] Both genetic and environmental risk factors contribute to the aetiology of RA with their impact varying depending on a patient’s rheumatoid factor (RF) and whether they have antibodies to citrullinated protein antigen (ACPA)[3,4]. Other environmental risk factors which have been studied in relation to the development of RA include alcohol intake, diet, vitamin D and education levels[9,10,11,12].
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.