Abstract
The present work studied the effect of the organophosphate insecticide, Chlorpyrifos (CPF) on the thyroid of albino rats and the possible ameliorative role of selenium (Se). Administration of CPF by gastric intubation (1/_(20) LD_(50), 6.7 mg/kg b.w. 5 days / week for 6 weeks) caused many histological alterations in the thyroid There was decrease in the size of follicles and amount of colloid, degeneration of follicular cells and congestion of blood vessels. Decrease of periodic acid Schiff (PAS) reaction in the cytoplasm of the follicular cells and colloids was observed. Besides, CPF caused marked reduction in triiodothyronine (T_3), thyroxine (T_4) and thyroid stimulating hormone (TSH). Animals treated with CPF and Se ((10 μg/Kg b.w, 5 days/week for 6 weeks) showed great amelioration and normalization of thyroid tissue architecture and increase in the thyroid hormones, T_3, T_4 and TSH. Since CPF toxicity may be due to its ability to induce oxidative stress in thyroid, it is possible that Se supply reversed CPF-induced thyroid toxicity by ameliorating the antioxidative defense of the rats.The present work studied the effect of the organophosphate insecticide, Chlorpyrifos (CPF) on the thyroid of albino rats and the possible ameliorative role of selenium (Se). Administration of CPF by gastric intubation (1/_(20) LD_(50), 6.7 mg/kg b.w. 5 days/week for 6 weeks) caused many histological alterations in the thyroid There was decrease in the size of follicles and amount of colloid, degeneration of follicular cells and congestion of blood vessels. Decrease of periodic acid Schiff (PAS) reaction in the cytoplasm of the follicular cells and colloids was observed. Besides, CPF caused marked reduction in triiodothyronine (T_3), thyroxine (T_4) and thyroid stimulating hormone (TSH). Animals treated with CPF and Se ((10 μg/Kg b.w, 5 days / week for 6 weeks) showed great amelioration and normalization of thyroid tissue architecture and increase in the thyroid hormones, T_3, T_4 and TSH. Since CPF toxicity may be due to its ability to induce oxidative stress in thyroid, it is possible that Se supply reversed CPF-induced thyroid toxicity by ameliorating the antioxidative defense of the rats.
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