Abstract
Abstract Background: The characterization of the rheological properties of topical formulations is important to predict their possible behaviour in clinical use. Methods: Two commercially
Highlights
Inflammatory bowel diseases (IBD) are a group of chronic and relapsing inflammatory disorders of the gastrointestinal tract (GI)
We have considered of interest to characterize and compare two beclomethasone dipropionate (BDP) suspension formulations for mucosal topical use
The G’ value decreased as temperature increased by 20%, since the sample is an aqueous suspension and at high temperatures such samples increase their viscose fluid component and their tendency to flow
Summary
Inflammatory bowel diseases (IBD) are a group of chronic and relapsing inflammatory disorders of the gastrointestinal tract (GI). IBD includes Ulcerative Colitis (UC) and Crohn’s Disease (CD). Whilst disease localization to the rectum, sigmoid and/or descending colon occurs in a discrete proportion of CD patients, UC always involves the rectum and may extend proximally up to the caecum; as such, most of IBD patients have the disease involving the left/distal colon [1]. 80% of all incident cases of UC are mild or moderate in severity, and more than 75% of patients have an endoscopic involvement distal to the splenic flexure [2], proximal extension is not uncommon and should be considered in case of worsening of the clinical conditions. The characterization of the rheological properties of topical formulations is important to predict their possible behaviour in clinical use
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