Abstract
Boronic acid-containing (co)polymers have fascinated researchers for decades, garnering attention for their unique responsiveness toward 1,2- and 1,3-diols, including saccharides and nucleotides. The applications of materials that exert this property are manifold including sensing, but also self-regulated drug delivery systems through responsive membranes or micelles. In this review, some of the main applications of boronic acid containing (co)polymers are discussed focusing on the role of the boronic acid group in the response mechanism. We hope that this summary, which highlights the importance and potential of boronic acid-decorated polymeric materials, will inspire further research within this interesting field of responsive polymers and polymeric materials.
Highlights
Boronic acid (BA) copolymers have been used for various applications over the years based on their responsiveness towards pH and towards 1,2- and 1,3-diol concentration
While the first approach is the most straightforward, it is most commonly performed via free radical polymerization, controlled radical polymerization under specific optimized conditions including high dilution and the presence of water to suppress crosslinking through boronic anhydride formation is possible
The results show reversible swelling of the nm Similar swelling behavior was observed upon the addition of saccharides in aqueous of the PBA-NP with a particle diameter roughly alternating between 130 nm and 150 solution
Summary
Boronic acid (BA) copolymers have been used for various applications over the years based on their responsiveness towards pH and towards 1,2- and 1,3-diol concentration. Such polymeric systems swellisin the up presence of glucose and removed from the blood stream, preventing hypoglycemic shock This possible application has or the increase in pH due to the shift of the BA-equilibrium to the charged side, introducing fascinated researchers for years and sparked numerous publications related to the swelling behavior a glucose-dependent permeability allowing its Kataoka use in etanal.autonomous insulin of cross-linked BA-containing polymer networks. Swelling speed shows a direct relationship with the pH of the aqueous solution originating from the BA equilibrium and an inverse relationship with the solution temperature caused by reduced accessibility of the BA groups in the temperature induced collapsed state [13] This same material was used in the fabrication of glucose responsive microcapsules through oil/water/oil emulsion polymerization of NIPAAm, mAPBA and a cross-linker in the water phase.
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