Abstract
Environment sensitive polymers have great potential in various applications. These polymers are self-regulated. In self-regulated schemes, the controlled or limited variable is noticed, along with the output of the system that is adjusted according to the variables. Through feedback information and without external involvement, the released rate is controlled. To control the rate mechanisms, the self-regulated schemes use many methods as, enzyme substrates reactions, pH-responsive drugs solubility, antibody interactions, competitive bindings, and metal concentration dependent hydrolysis. The roles of environment sensitive polymers in self-regulated drug delivery systems are discussed in this paper.
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