Abstract
Objective To analyze the relationship between the expression of Golgi protein-73 (GP73) and CD133 with clinical biological behaviors of colorectal carcinoma.Methods Immunohisto-chemical method was used to assess the expression of GP73 and CD133 in 82 cases of colorectal carcinoma tissues and non-cancerous adjacent colorectal tissues.Results The expression rate of GP73 in colorectal carcinoma tissues was higher than that in non-cancerous adjacent colorectal tissues (84.15％ vs.64.63％,P ＜0.01).The expression level of GP73 was related to histology grade and serosa invasion of colorectal carcinoma (P ＜ 0.05).Tthe expression rate of CD133 in colorectal carcinoma tissues was higher than that in non-cancerous adjacent colorectal tissues (47.56％ vs.15.85％,P ＜0.01),and the expression of CD133 was closely related with TNM stage and lymph node metastasis of colorectal carcinoma (P ＜0.05).Conclusion GP73 and CD133 in colorectal carcinoma tissues might be used as markers for assessing the clinicopathological features. Key words: Colorectal carcinoma; Golgi protein-73; CD133
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