Expression and clinical significance of metastasis suppressor 1 and Fascin in colorectal carcinoma

Abstract

Objective To study the relationship between metastasis suppressor 1 (MTSS1) and Fascin with clinical and pathological characteristics in colorectal carcinoma. Methods Immunohistochemical method was used to detect the expression of MTSS1 and Fascin in 94 cases of human colorectal carcinoma tissues and non-cancerous adjacent colorectal tissues. Results The expression rate of MTSS1 was 38.30% (36/94) in colorectal carcinoma tissues, and 98.94% (93/94) in non-cancerous adjacent colorectal tissues (P<0.01). The expression rate of Fascin was 62.77% (59/94) in colorectal carcinoma tissues, and 25.53% (24/94) in non-cancerous adjacent colorectal tissues (P<0.01). The expression of MTSS1 was related to serosa invasion, TNM stage and lymph node metastasis (P<0.05), and there was a close relationship between the expression of Fascin and histology grade, TNM stage and lymph node metastasis (P<0.05). Conclusion The low expression of MTSS1 and high expression of Fascin could confer a poor prognosis of patients with colorectal carcinoma. Key words: Metastasis suppressor 1; Fascin; Colorectal carcinoma