Expression and correlation analysis of metastasis suppressor 1 and E-cadherin in colorectal cancer

Abstract

Objective To investigate the difference of metastasis suppressor 1(MTSS1) and E-cadherin expression in colorectal cancer and its clinical significance. Methods From October 2004 to October 2017, two hundred and twenty-three cases of colorectal cancer in the Fifth Affiliated Hospital of Sun Yat-sen University were retrospectively analyzed. Immunohistochemical technique was used to detect the expression of MTSS1 and E-cadherin in colorectal cancer tissues, and the correlation between their expression and clinicopathological characteristics was compared. Results The positive expression rates of MTSS1 and E-cadherin in cancer tissues were significantly lower than those in normal intestinal tissues and paracancerous tissues (P<0.001). MTSS1 and E-cadherin protein expression were significantly correlated with tumor differentiation, depth of local infiltration, vascular invasion, clinical stage, lymph node metastastastasis and liver metastasis (all P<0.05). There was a positive correlation between the expression of MTSS1 and E-cadherin in colorectal cancer tissues (r=0.417, P<0.001). Survival analysis showed that the prognosis of MTSS1, E-cadherin single negative group was worse than that of positive group (χ2=8.764, 4.771, P=0.003, 0.029), and double negative patients had worse prognosis (χ2=13.940, P=0.005). Conclusions The expression of MTSS1 and E-cadherin is positively correlated in colorectal cancer. The expression of MTSS1 and E-cadherin is low in the cases of low differentiation, deep invasion, advanced stage, local or metastatic liver metastasis. MTSS1 and E-cadherin may play a synergistic role in the invasion and metastasis of colorectal cancer. The combined detection has certain clinical value in predicting liver metastasis and judging prognosis. Key words: Colorectal neoplasms; MTSS1; E-cadherin; Immunohistochemistry