Abstract
Objective To analyze the relationship between the expression of Stathmin and endoglin-marked microvessel density (MVD) and clinicopathological features of colorectal carcinoma.Methods Immunohistochemistry was used to detect the expression levels of Stathmin and MVD marked with endoglin in 46 cases of human colorectal carcinoma tissues and non-cancerous adjacent colorectal tissues.Results The expression rate of Stathmin was 69.57％ (32/46) in colorectal carcinoma tissues,and 34.78％(16/46) in non-cancerous adjacent colorectal tissues (P ＜0.01).The expression of Stathmin was related to histologic grade,serosa invasion,TNM stage and lymph node metastasis in colorectal carcinoma (P ＜0.05).The expression of MVD marked with endoglin was (68.27 ± 5.66) in colorectal carcinoma tissues,and (41.51 ±4.52) in non-cancerous adjacent colorectal tissues (P ＜0.01).The expression of MVD was related to serosa invasion,TNM stage and lymph node metastasis (P ＜ 0.05).Conclusion The combined detection of Stathmin and endoglin may be used to determine the biological behaviors of colorectal carcinoma. Key words: Stathmin; Endoglin; Microvessel density ; Colorectal carcinoma
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