Significance of AKT2 and deleted in liver cancer-1 expression in colorectal carcinoma

Abstract

Objective To analyze the relationship between the expression of AKT2 and deleted in liver cancer-1 (DLC-1) with biological behaviors of colorectal carcinoma.Methods Envision immunohistochemical method was used to assess the expression of AKT2 and DLC-1 in 70 cases of human colorectal carcinoma tissues and non-cancerous adjacent colorectal tissues.Results The expression rate of AKT2 was 60.00％ (42/70) in colorectal carcinoma tissues,and 21.43％ (15/70) in non-cancerous adjacent colorectal tissues (P ＜0.01).The expression rate of DLC-1 was 31.43％ (22/70) in colorectal carcinoma tissues,and 84.29％ (59/70) in non-cancerous adjacent colorectal tissues (P ＜0.01).The expression of AKT2 was related to histology grade,serosa invasion,TNM stage and lymph node metastasis (P ＜ 0.05).There was a close relation between the expression of DLC-1 and serosa invasion,TNM stage and lymph node metastasis (P ＜ 0.05).Conclusion Examination of expression of AKT2 and DLC-1 may be of value in evaluating the biological behaviors of colorectal carcinoma. Key words: AKT2; Deleted in liver cancer-1 ; Colorectal carcinoma