Relationship between TREM-1 gene polymorphism and susceptibility to coronary atherosclerotic heart disease

Abstract

Objective To explore the relationship between gene polymorphisms of triggering receptor expressed on myeloid cells-1 (TREM-1) rs2234237A/T, rs9471535A/G and susceptibility to coronary atherosclerotic heart disease(coronary heart disease for short, CHD). Methods A case-control study. 120 patients with CHD (CHD group) and 90 healthy people (Normal control group) were selected from November 2016 to April 2017 in Jingzhou Central Hospital. The single nucleotide polymorphisms(SNPs) of TREM-1gene (rs2234237 and rs9471535)were analyzed using Sanger method in all subjects. Comparing baseline clinical data and the distribution of genotype frequencies in the two groups. Non conditional logistic regression was used to analyze the relationship between TREM-1 gene ( rs2234237 and rs9471535) polymorphisms and susceptibility to CHD. Results The proportion of gender as well as level of age, body mass index, total cholesterol, triglyceride and low density lipoprotein cholesterol were not statistically significant between the two groups(χ2 =0.575, P>0.05; t=-1.670, P>0.05; t=-1.719, P>0.05; t=1.011, P>0.05; t=-1.834, P>0.05; t=0.474, P>0.05, respectively), while the proportion of smoking, hypertension and diabetes as well as level of high density lipoprotein cholesterol and fasting plasma glucose were statistically significant between the two groups (χ2 =4.321, P 0.05). Conclusions TREM-1 gene rs2234237 A/T and rs9471535 A/G polymorphisms are significantly associated with susceptibility to CHD . rs2234237 TT genotype and rs9471535 GG genotype might act as protective factors of CHD.(Chin J Lab Med, 2018, 41: 436-441) Key words: Coronary disease; Triggering receptor expressed on myeloid cells-1; Polymorphism, single nucleotide; Disease susceptibility