Relationship between blood uric acid and degree of coronary artery stenosis

Abstract

Objective To study the blood uric acid levels in the patients with or without coronary artery disease, as well as in the patients with different degrees of coronary artery stenosis, and to investigate the relationship between blood uric acid level and the degree of coronary artery stenosis. Methods 3803 patients who hospitalized frSom January 11999 to December 312006 underwent coronary angiography and uroxisome method to detect the blood uric acid. Results The age of the 2772 patients with coronary artery stenosis was (64±11 ), significantly elder than that of the 1031 patients without coronary artery stenosis [ (58±12), P＜0.01 ]. The percentage of males of the patients with coronary artery stenosis was 69.8%,significantly higher than that of the patients without coronary artery stenosis (50.5%, P＜0.01 ). The proportions of those with history of hypertension, diabetes, cerebral stroke, blood lipid abnormality,smoking, damaged renal function, and use of diuretics (all P＜0.01 ). The blood uric acid level of the patients with coronary artery stenosis was (328±103) μmol/L, not significantly different from that of the patients without coronary artery stenosis (314±98) μmol/L (P = 0. 009). Coronary artery stenosis was significantly correlated to all of the clinical parameters: blood uric acid, hypertension, diabetes, smoking,use of diuretics, blood lipid abnormality, damaged renal function, age and gender (all P＜0.001 ) , and blood uric acid level was significantly correlated with all the clinical parameters too ( all P＜0.05 ) , except age. Multivariable logistic regression showed that blood uric acid level was still independent predictors of coronary artery disease. The more extensive the coronary artery stenosis the higher the blood uric acid level (P＜0.001 ). Conclusion Coronary artery stenosis and blood uric acid level are independently relevant.The more extensive the coronary artery stenosis was, the higher the blood uric acid level was. Key words: Coronary disease; Uric acid; Regression analysis