Abstract
Objective To investgate the expression of survivin and p53 and to evaluate their relationship in colorectal carcinoma.Methods The expression of survivin and p53 were evaluted using immunohistochemistry in 58 cases of colorectal carcinoma tissue,25 cKses of paracarcinoma tissue and 39 cases of normal colonia membrance tissue.Results The positive rates of survivin and p53 in colorectal carcinoma were 72.4%(4:2/58)and 63.8%(37/58).The positive rates of survivin and p53 in colorectal carcinoma were significantly higher than paracarcinoma tissue and normal colonia membrance tissue(P＜0.05).Survivin and p53 expression were related to metastasis of colorectal carcinoma(P＜0.05).The expression of survivin was obviously correlated with p53 in colorectal carcinoma(r=0.291,P=0.020).Conclusion Overexpreasion of survivin may play a crucial role in the origin and development of colorectal carcinoma. Key words: Coloric neoplasms; Inhibitor of apoptosis proteins; Tumor suppressor protein p53
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
