Abstract
Diabetes mellitus is a chronic disorder in human and responsible for different complications and also causes mortality and morbidity. A wide number of herbal products are employed in the treatment of diabetes for their better efficacy and safety compared to synthetic medicine. The present studies have established the antidiabetic potential and rejuvenating capacity of kidney tissues under the effect of extract. Diabetes was induced in the Swiss albino mice by injecting alloxan at the dose of 150 mg/kg body weight and aqueous extract ofMomordica charantiafruits at doses of 100 mg/kg body weight and 250 mg/kg body weight was administered orally for three weeks. After 21 days of treatment of the aqueous extracts ofMomordica charantiasignificantly reduces serum glucose level, kidney function tests, lipid peroxidation as well as histopathological study also did show adverse alternation in the morphological architecture of the kidney tissue. Thus, from this study we concluded thatMomordica charantiaexhibited significant antihyperglycemic and rejuvenating capacity of kidney tissues activities in alloxan induced diabetic mice.
Highlights
Diabetes mellitus (DM) is possibly the world’s fastest growing metabolic disorder and as the knowledge of the heterogeneity of this disorder increases so does the need for more appropriate therapies [1]
Diabetes is associated with the generation of reactive oxygen species (ROS) which cause oxidative damage, to heart, kidney, eyes, nerves, liver, small and large blood vessels, and immunological and gastrointestinal system [1, 3]
Recent studies indicate that reactive oxygen species (ROS) play a key intermediate role in the pathophysiology of diabetic nephropathy [4]
Summary
Diabetes mellitus (DM) is possibly the world’s fastest growing metabolic disorder and as the knowledge of the heterogeneity of this disorder increases so does the need for more appropriate therapies [1]. Scientists have identified 3 groups of constituents thought to be responsible for blood sugar lowering action of bitter melon; one of these is a compound called charantin which is composed of βsitosterol-glucoside and 2-5-stigmatadien-3-β-ol-glucoside and can potentially replace treatment by insulin [18]. Another compound, polypeptide-p (plant insulin), found in seeds and fruits of bitter melon is similar to insulin in composition, so it can be of a great benefit in therapy of type 1 diabetes [19]. Compounds known as oleanolic acid glycosides have been found to improve glucose tolerance in type 2 diabetes [20]
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