Abstract
Aim: The present study investigates the hypoglycemic and hematopoetic potential of the seed extracts of Anethum graveolens. Context: A. graveolens (Apiaceae) is an Indian traditional herb. Leaves and seeds of this plant are known for their medicinal properties. Leaves are best used in fresh form while seeds are used in dried form. Materials and Methods: Control and alloxan-induced diabetic mice were orally treated once in a day with aqueous and ethanol extracts for the period of 15 days and the effect of both extracts on body weight, organ weight and blood glucose level were determined. For the hematological study, aqueous (3.04 g/kg), ethanol extracts (6.98 g/kg) and carvone (100 mg/kg body weight) were orally administered once in a day to male Swiss albino mice. While control mice were supplemented with normal saline. Results: A significant decrease (P<0.05) in blood glucose level after administration of aqueous extract was observed along with a significant increase in body and organ weight in alloxan induced diabetic mice after the treatment with plant extracts. Moreover carvone and the aqueous extract significantly increased (P<0.05) red blood cell count (11.94 and 10.42%), hemoglobin (15.55 and 15.06%), Mean Corpuscular Haemogolobin (MCH) (2.80 and 4.80%), Mean Corpuscular Haemoglobin Content (MCHC) (8.16 and 9.57%) when compared with control. While in ethanol extract no such changes were observed except in WBC, which was increased by 9.43%. Conclusion: The result suggests an anti-diabetic property of the aqueous and ethanol extracts. Both extract and carvone also have beneficial effect on hematological parameters.
Highlights
Anethum graveolens L. (Apiaceae), commonly known as “dill seed”, is an annual herb found in Mediterranean region, Europe, and Central and South Asia
While in ethanol extract no such changes were observed except in WBC, which was increased by 9.43%
There was a significant increase in the blood glucose level was observed in alloxan induced diabetic mice after 48 h of alloxan monohydrate intraperitoneal injection
Summary
Anethum graveolens L. (Apiaceae), commonly known as “dill seed”, is an annual herb found in Mediterranean region, Europe, and Central and South Asia. A. graveolens is used both as a medicine and an aromatic herb and is shown to have therapeutic properties [1]. It is used in Iranian folk medicine as an anti-hypercholesterolaemic plant [2]. The presence of flavonoids, phenolic compounds and essential oil constituents in seeds of A. graveolens make it an important component for the preparation of gripe water [8] A. graveolens has some pharmacological effects, such as anti-microbial [9,10,11], anti-spasmodic, antisecretary, and mucosal protective effects [3], A. graveolens has significant lipid lowering effects and is a promising cardioprotective agent [12] and antioxidant properties have been reported [13]
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