Abstract
The current study presents a packed column gas chromatographic technique for the estimation of glycerin using a flame ionization detector from a marketed hair tonic in presence of resorcinol, ethanol, biotin, keratin hydrolysate, undecylenic acid alkylolamide (hyalkyl HBU), D-biotin, nicotinic acid, and polyvinylpyrrolidone. The validation studies show the proposed method to be specific, sensitive, precise, and accurate. The method is found to be linear in the concentration range 1.25 mg/mL to 10.02 mg/mL with r2 value 0.99. The limit of detection and the limit of quantitation were 0.01 mg/mL and 0.05 mg/mL, respectively. The method does not involve any complex sample preparation procedure and is therefore suitable for regular analysis of glycerin from marketed hair tonic.
Highlights
Glycerin is a trihydroxy alcohol having a number of commercial applications
In case of pharmaceutical formulations glycerin is manly used as an excipient [1] and variation in proportion may potentially affect the usefulness of such formulations
As humectants in cosmetic formulations and in hair tonics where it has been used as an active ingredient [7] a variation in the proportion of glycerin may spoil the quality of the product
Summary
Glycerin is a trihydroxy alcohol having a number of commercial applications. It is colourless, odourless, syrupy liquid having a sweet taste and finds wide applications in many liquid pharmaceutical formulations [1]. Other applications include its use as a lubricant and humectants and in cosmetics [2,3,4] It is used in almost all types of personal care products including medicated hair tonics [2]. It has been tried in nursing pig diet [5] and diet of bulls. As humectants in cosmetic formulations and in hair tonics where it has been used as an active ingredient [7] a variation in the proportion of glycerin may spoil the quality of the product. The process is suitable for routine analysis of glycerine from hair tonics
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