Abstract
Functional and anatomical small animal imaging represents one of the most promising tool in preclinical research capable of in vivo quantitative analysis of induced abnormalities in animal models and evaluation of metabolic, functional, and morphological consequences of genomic alterations in order to establish new therapeutic and diagnostic drugs. Among all the methods, SPECT imaging has recently benefited from numerous technological developments leading to submillimeter spatial resolutions with increasing detection sensitivity. Moreover, availability and sensitivity of single photon radiotracers are serious advantages of the method, which should play an important role in pre clinical imaging. The aim of this article is to present and discuss these small animal SPECT imaging advances.
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