Abstract
This study was aimed to evaluate the pharmaceutical quality of ranitidine hydrochloride, tiemonium methylsulfate and domperidone tablets manufactured in Bangladesh. Ten samples of Ranitidine Hydrochloride, Tiemonium Methylsulfate and Domperidone solid dosage forms available in Bangladesh drug market were assayed spectrophotometrically and their various physical parameters such as weight variation, friability, disintegration, dissolution and hardness were analyzed according to British Pharmacopoeia (BP) and United States Pharmacopoeia (USP). Among them seven ranitidine, seven timonium and seven domperidone samples were meet the BP specification (95 – 105% of claimed potency). Study revealed that eight ranitidine, ten tiemonium and seven domperidone formulations of different companies meet the USP specification for in vitro dissolution test in first 30 minutes.
Highlights
H2-receptor antagonists are useful in the prevention of stress ulceration and recurrence of gastric and duodenal ulcer
Ranitidine hydrochloride is used for the treatment of Helicobacter pylori eradication, gastro esophageal reflux disease and erosive esophagitis[6,7]
All together seven ranitidine samples, seven timonium samples and seven domperidone samples were within the British Pharmacopoeia (BP) specification (95 – 105% of claimed potency), which is 70% of tested brands
Summary
H2-receptor antagonists are useful in the prevention of stress ulceration and recurrence of gastric and duodenal ulcer. Ranitidine hydrochloride (Figure 1), chemically N, N-dimethyl-5-[2-(1- methylamine-2-nitrovinyl)-ethylthiomethyl] furfurylamine hydrochloride (Figure 1) is a H2-receptor antagonist and is widely used in short term treatment of duodenal ulcer and in the management of hypersecretory conditions[2]. It is prescribed in erosive esophagitis, gastric irritation. It was thought that formulation residing at absorption window for prolonged period may be a useful approach to enhance bioavailability of ranitidine hydrochloride[3] It is effective by both parenteral and oral routes of administration[4]. Ranitidine can be found in Creative Commons Attribution 4.0 International License
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