Pharmaceutical Equivalent Study of Losartan Potassium Formulation available in Karachi, Pakistan

Hameed A,Naveed S,Abbas Ss,Qamar F

doi:10.4172/jbb.1000310

Abstract

The purpose of this study is to check pharmaceutical equivalence of altered brands of Losartan Potassium tablets available in Karachi, Pakistan. Two different brands of Losartan Potassium tablets (50 mg) were investigated in the study. Five Quality Control (QC) parameters: Weight variation, thickness test, hardness, friability and disintegration tests were carried out as specified by BP/USP (British Pharmacopoeia and United State Pharmacopoeia). The result of study revealed that all above mentioned tests are in accordance with BP/USP. Both brands of Losartan Potassium tablets are Pharmaceutical Equivalent.

Highlights

Losartan is a phenyl tetrazole deputize for imidazole compound and it is an Angiotensin Receptor Blocker II (ARB II) type I antagonist and it is used in the treatment of hypertension
The appearance of losartan potassium is white or may be off white crystalline powder where its melting point is between 263-265°C and it is freely soluble in water
Weight variation test of Losartan Potassium tablets proved statistically that all the tablets were in accordance to the BP/USP requirements as shown in the Tables 1-3

Summary

Introduction

Losartan is a phenyl tetrazole deputize for imidazole compound and it is an Angiotensin Receptor Blocker II (ARB II) type I antagonist and it is used in the treatment of hypertension. Administration of Losartan results in a decrease Total Peripheral Resistance (TPR) and cardiac venous return [1] Their pharmacologic effect is similar to that of the Angiotensin Converting Enzyme (ACE) inhibitors, since they produce the arteriolar as well as venous dilation and blocks aldosterone secretion, lowers the blood pressure, salt content and water retention [2]. Losartan is specific or selective type I Angiotensin II receptor (AT1) antagonist They block receptor as a result decrease in blood pressure (Rennin-Angiotensin-Aldosterone System (RAAS)) [5]. Long term use of losartan potassium develops angioedema [2]

Objectives

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Discussion

Conclusion