Abstract
Dexlansoprazole (DSP) is a proton pump inhibitor, used in the treatment of gastroesophageal reflex disease (GERD) and ulcer colitis. DSP acts by reducing the quantity of acid in the stomach. DSP is an acid liable drug which can bed egraded in acidic pH of the stomach. A coating method was employed to delay the release of drug in stomach which can prolong the pharmacological action.Sugar spheres (#25, #30) have been used as inert core material for drug coating using the technique of pelletization. Delayed coating, IR coating and ER coating of drug was done by using L-HPC-31, HPMC phthalate-55, Eudragit-RSPO and Eudragit-RLPO respectively. Among the different batches F14 formulation containing 25:75 ratio of immediate release and extended delayed release coating was selected, as retardation of the drug was observed in acidic pH of stomach.
Highlights
Gastroesophageal reflux disease (GERD) is a chronic symptom of mucosal damage caused by stomach acid coming up from the stomach into the oesophagus
DSP is proton pump inhibitor used in gastro-oesophageal reflex disease (GERD) which degrades at acidic pH in stomach
Sugar sphere (#25#30) was used as inert core material which was subjected to drug loading, barrier coating, immediate delayed releasing and extended delayed release coating
Summary
Gastroesophageal reflux disease (GERD) is a chronic symptom of mucosal damage caused by stomach acid coming up from the stomach into the oesophagus. The most common symptoms include heart burn and regurgitation Medications such as proton pump inhibitors, H2 receptor blockers and antacids are used in the treatment of GERD. DSP is a proton pump inhibitor drug used in the treatment of GERD[1] It is degraded in acidic stomach pH, lacking in pharmacological action of the drug. Most common pelletization techniques include compaction, agitation, layering and globulation[7,8] Inert material such as sugar sphere is coated with drug and various polymers such as hydroxypropyl cellulose-31, hydroxylpropyl methyl cellulose phthalate-55 and Eudragit (RSPO and RLPO).The main purpose of coating is for delayed, immediate and extended delayed release of DSP. Coating of DSP with various polymers prevents the rapid degradation in acidic pH of stomach, enhances pharmacological activity
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