Abstract
Dexlansoprazole (DSP) is a proton pump inhibitor, it used to treat GERD and ulcer colitis. DSP works by decreasing the volume of acid in the stomach. DSP is an acid-labile medication that may be destroyed in the stomach's acidic pH. A coating technique was used to postpone drug release in the stomach, which can extend pharmacological activity. Shellac can be used to develop the sustain release tablet of dexlansoprazole as retardation of the drug (dexlansoprazole) was observed in the acidic pH of the stomach, and hence a sustain coated dexlansoprazole tablet was prepared and evaluated. The coating's primary function is to allow for the delayed, immediate, and prolonged delayed release of DSP. DSP coating with different polymers inhibits faster degradation in the acidic pH of the stomach, therefore increasing pharmacological action. DSP coating with different polymers inhibits fast degradation in the stomach's acidic pH, enhancing pharmacological action. The major function of the coating is to enable for the delayed, immediate, and prolonged delayed release of DSP. DSP coating with different polymers inhibits fast breakdown in the stomach's acidic pH, enhancing pharmacological action.
Highlights
Gastroesophageal reflux disease (GERD) is a persistent symptom of mucosal injury caused by stomach acid refluxing into the esophagus from the stomach
5.1 Determination of λmax and selection of Analytical Wavelength The typical Dexlansoprazole solution is scanned at wavelengths ranging from 200 to 400 nm
The wavelength used for Dexlansoprazole determination is 283.0 nm (Figure 1)
Summary
Gastroesophageal reflux disease (GERD) is a persistent symptom of mucosal injury caused by stomach acid refluxing into the esophagus from the stomach. The most common symptoms include heartburn and regurgitation Medications such as proton pump inhibitors, H2 receptor blockers and antacids are used in the treatment of GERD. DSP is a proton pump inhibitor drug used in the treatment of GERD” (1) It is degraded in acidic stomach pH, lacking in pharmacological action of the drug. Palletization of DSP and coating of various polymers prevents rapid degradation and produces prolonged action Pellets are fine powder or granules of bulk medicines and excipients agglomerated together (2). It offers a number of advantages, including enhanced product appearance, reduced dosage dumping, increased safety and efficacy, and free dispersion in the gastro-intestinal tract.
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