Abstract
Objective: The current research is for improving patient compliance by reducing dosing frequency of ocular ketorolac tromethamine used for allergic conjunctivitis through preparation of minitablet for ocular insertion. Method: Ocular mini tablet was prepared by direct compression method using xanthan gum, chitosan and carbopol 943P as polymers to prepare the mini tablet for ocular insertion. The mini tablets were evaluated for drug content, weight variation, bioadhesion, water uptake and swelling behavior, in vitro drug release and ocular irritation. Results: The best formula (F1) containing 1% chitosan gave mini tablets with dimension (3 × 0.7 mm) with satisfactory physical properties and 100% release after 12 hours to be inserted anteriorly. Conclusion: This work succeeded in preparing ocular mini tablet of ketorolac tromethamine to be inserted anteriorly for the treatment of allergic conjunctivitis. As promising sustained release drug delivery system to be a good alternative for the conventional treatment regimen to improve patient compliance by reducing frequent doses with no irritation.
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