Development of Sustained Release Drug Delivery System: A Review

Abstract

Sustained release drug delivery system can be a maj or advance toward solving the problem concerning drugs have a short half-life are eliminated quickly from blood c irculation require frequent dosing. To avoid this p roblem, oral sustained release formulations have been developed in an attempt to release the drug slowly into the g .i.t and maintain a constant drug concentration for long per iod of time. Purpose of review article is designing sustained release drug delivery system is to reduce the frequ ency of dosing, reduce the dose and provide uniform drug delivery. Present review article compile various fo rmulation approaches for sustained release drug del ivery system such as objectives of SRDDS, disadvantages of conventional dosage form, advantages, factors in designi ng of SRDDS, drug selection , polymers used, models and comparison of dissolution profile , characterization of sustained release tablets.