Abstract
In this present study combination tablets containing diclofenac sodium, dried aluminium hydroxide gel and magnesium trisilicate were prepared using customized formula and common properties of tablets like hardness, thickness, diameter, weight and disintegration time along with the flow properties of granules were determined. Our results showed that most properties of the tablets complied with the official limit of acceptance. The pH, water absorption index, dissolution behavior and organoleptic property of tablets were also checked. Results showed that pH of combination tablets was 8.27 ± 0.04 when dissolved in purified water. Water absorption index varied from 0.1% to 0.2%. Tablets were undergone dissolution by 85% and 96% in 45 and 90 minutes respectively. In the study the organoleptic properties of the tablets remained the same over a period of 60 days.
Highlights
In recent era non steroidal anti-inflammatory drugs (NSAIDs) have received great attention in treating inflammation and combating pain resulting from cellular damage caused by mechanical injury and infection
The main reason behind such attention is that NSAIDs are devoid of narcotic effects produced by the narcotic analgesics and these are called non-narcotic analgesics [1]
This study was conducted for the preparation and quality evaluation of combination tablets containing diclofenac sodium and a mixture of aluminium hydroxide gel and magnesium trisilicate
Summary
In recent era non steroidal anti-inflammatory drugs (NSAIDs) have received great attention in treating inflammation and combating pain resulting from cellular damage caused by mechanical injury and infection. Other salt form of this acid that is commercially available is diclofenac potassium but the sodium salt perhaps is the better choice because of its stability, pleasant taste and odor This drug offers a wide range of versatility in uses. Most importantly this drug shows better and stronger anti-inflammatory action than paracetamol, indomethacin and other NSAIDs. It is reported that diclofenac sodium being a salt of an organic acid has the tendency to get accumulated non- at the sites of inflammation. It is reported that diclofenac sodium being a salt of an organic acid has the tendency to get accumulated non- at the sites of inflammation Such phenomenon in turn reduces intracellular concentration of free arachidonic acid either by altering the release or uptake of the acid and strengthens drug action [1]. According to the report of Bureau of Statistics, 2003 here one physician spends less than a minute for counseling a patient
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