Abstract
To evaluate binding potential of Prunus domestica gum in tablets formulations. Six tablet batches (F-1B to F-6B) were prepared by wet granulation method, containing Avicel pH 101 as diluent, sodium diclofenac as model drug using 10, 15 and 20 mg of Prunus domestica gum as binder and PVP K30 was used as standard binder. Magnesium stearate was used as lubricant. Flow properties of granules like bulk density, tapped density, Carr index, Hausner’s ratio, angle of repose as well as physical parameters of the compressed tablets including hardness, friability, thickness and disintegration time were determined and found to be satisfactory. The FTIR spectroscopic analysis showed that the formulation containing plant gum is compatible with the drug and other excipients used in tablets formulation. Hence the plant gum has role as a potential binder in tablets formulations. The dissolution profile showed that tablets formulations containing Prunus domestica gum 15 mg/200 mg of total weight of tablet as binder showed better results as compared to PVP K30.
Highlights
Gum is a by-product obtained as an outcome of metabolic mechanism of plants
Diclofenac sodium is a non-steroidal anti-inflammatory drug (NSAID), which is poorly soluble in water and freely soluble in organic solvent like methanol
No work has been done on Prunus domestica gum as tablet binder
Summary
Gums obtained from natural sources either absorb water to form a viscous solution or water soluble. Diclofenac sodium is a non-steroidal anti-inflammatory drug (NSAID), which is poorly soluble in water and freely soluble in organic solvent like methanol. Plant gums have been used as binders in tablet formulations. They are useful for imparting the structural strength required during the processing, handling and packaging of tablets as well as these plant gums are of non-toxic nature and widely available. No work has been done on Prunus domestica gum as tablet binder. The gum is widely available and need to be evaluated by using as an excipient in tablet formulations
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