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It is highly delighted to introduce the 2021 4th International Conference on Computer Information Science and Application Technology (CISAT 2021), which held on July 30-August 1, 2021 in Lanzhou, China. CISAT 2021 is to bring together innovative academics and industrial experts in the field of computer information science and application technology to a common forum. The primary goal of the conference is to promote research and developmental activities in computer information science and application technology and another goal is to promote scientific information interchange between researchers, developers, engineers, students, and practitioners working all around the world. The conference will be held every year to make it an ideal platform for people to share views and experiences in computer information science and application technology and related areas.About 180 participants from academic, high-education institutes and other organizations took part in the conference. The conference model was divided into two sessions, including oral presentations and keynote speeches. In the first part, some scholars, whose submissions were selected as the excellent papers, were given 15 minutes to perform their oral presentations one by one. Then in the second part, keynote speakers were each allocated 30-45 minutes to hold their speeches. We were very honored to three professors as our Conference Chairs.In the keynote presentation part, we invited eight professors as our keynote speakers. The first keynote speaker, Prof. Anhui Liang, from Shandong University of Science and Technology, China. He performed a speech: Biological Optical AI on the Retinas of Human and Vertebrates, Biological Optical Fiber Couplers and Biological Transistors. The second keynote speaker, Prof. Tao Zhang, from China Aerospace Science and Industry Coparation Limited. He presented an insightful speech: Intelligent Applications of Loan Risk Control Based on Financial Big Data Technology. Prof. Jeng-Shyang Pan, from Shandong University of Science and Technology, China. He delivered a wonderful speech: Overview of Swarm Intelligence Algorithm. Prof. Yuanchang Zhong, from Chongqing University, China, performed a speech: An Vehicle-mounted Tank Valve Monitoring System Based on BeiDou Navigation Satellite Tracking. Prof. Mingfu Zhao, from Chongqing University of Technology, China. He presented a talk: Intelligent optical fiber sensing technology and application. Prof. Wei William LEE, from Zhejiang University of Technology, China, performed a speech: Application of Blockchain in Financial Services. Dr. Zhixiang Liu, from Shenzhen Association of IC Industry. He presented an insightful speech: Overview of IC Industry. Our finale keynote speaker, Prof. Nianbing Zhong, from Chongqing University of Technology, China. He delivered a speech: Intelligent fiber optic sensing technologies for monitoring biofilm growth.The proceedings present a selection of high-quality papers submitted to the conference by researchers from universities, research institutes, and industry. All papers were subjected to peer-review by conference committee members and international reviewers. The papers were selected based on their quality and their relevance to the conference. The proceedings present recent advances in the fields of Computational Science and Algorithms; Intelligent Computing and Artificial Intelligence; Software Process and Data Mining and others related research.I would like to express special gratitude to members of the conference committee and organizers of the conference. I would also like to thank the reviewers for their valuable time and advice which helped in improving the quality of the papers selected for presentation at the conference and for publication in the proceedings. Finally, I want to thank the authors, the members of the organizing committee, the reviewers, the chairpersons, sponsors, and all other conference participants for their support of CISAT 2021.The Committee of CISAT 2021List of titles Committee member, Conference Chairs, Technical Committee Chair, International Technical Committee are available in this Pdf.