Polyvinyl alcohol nanofibers encompass Chitosan/Tripolyphosphate nanogels for controlled release of gemifloxacin antibiotic

Abstract

To reduce the risk of antibiotics overuse and associated side-effects, development of drug delivery systems (DDS) are necessary. In the present study tripolyphosphate (TPP)/chitosan (CS) nanogels were synthesized and loaded into Polyvinylalcohol (PVA) nanofibers through electrospinning –elctrospraying. The synthesized electrospun scaffolds applied for controlled release of antibiotics e.g. gemifloxacin. For this purpose in the first step Chitosan/Tripolyphosphate (CS/TPP) Nanogels containing antibiotic drugs were synthesized. In the second step the PVA nanofibers were produced using electrospinning while the nanogels were simultaneously electrosprayed on the surface of as-prepared PVA and so the nanofibrous scaffolds including antibiotics loaded nanogels were fabricated (CS/TSS + antibiotics@PVA).Aside from synthesis and characterization of CS/TSS + antibiotics@PVA nanofibers, the antibiotics load and release experiments were performed for evaluation their DDS potential application. Both pristine and drug-loaded samples were analyzed via Fourier transform infrared spectroscopy (FT-IR), Ultra-violet visible spectroscopy (UV–vis), Transmission electron microscopy (TEM) and Zeta potential test. Spectroscopic results indicate that the uptake of each antibiotic candidate is performed effectively in CS/TSS + antibiotics@PVA nanofibers. The release experiments confirm the controlled response of nanofiberes and steady deliverance of antibiotics. Fig. 1 shows the SEM images of preparednanofibers and nanogels, ATR-FTIR spectrum and obtained release pattern.