Preparation And Characterization of Polyvinyl Alcohol Nanofiber Loaded With Mafenide For Sustain Release

Abstract

This paper delves into the intricate process of preparing and characterizing Polyvinyl alcohol (PVA) nanofibers loaded with Mafenide to achieve sustained release functionality. The synthesis involves the careful integration of Mafenide, a pharmaceutical agent known for its antimicrobial properties, into PVA nanofibers. This combination holds promise for controlled drug delivery applications. The preparation begins with the electrospinning technique, a method widely employed for creating nanofibrous structures. During this process, the Mafenide is incorporated into the PVA matrix, forming a composite material. The choice of Polyvinyl alcohol as the base material is strategic, given its biocompatibility and excellent film-forming properties. The characterization phase involves a comprehensive analysis of the resulting nanofibers. Techniques such as scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR). are employed to examine the morphology and chemical composition of the nanofibrous system. These analyses provide insights into the structural integrity and the successful incorporation of Mafenide. The study focuses on the sustained release aspect, aiming to understand how the loaded Mafenide interacts within the PVA nanofibers over time. This sustained release mechanism is crucial for pharmaceutical applications, offering prolonged therapeutic effects and minimizing the need for frequent administration. The potential benefits of this research lie in the development of an efficient drug delivery system.