Abstract
Polycystic kidney disease is a common inherited disorder that primarily follows an autosomal dominant inheritance pattern, leading to significant kidney problems. Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent form, representing the leading genetic cause of end-stage kidney disease worldwide. Characterised by clusters of fluid-filled cysts in both kidneys, ADPKD is a multisystem and progressive disease involving organs such as the heart, liver, and pancreas. Understanding ADPKD's genetic basis, clinical presentations, and progression is crucial for GPs, as early detection and appropriate management can significantly improve patient outcomes. This article provides a comprehensive overview of ADPKD for GPs, focusing on diagnosis, management, and clinical implications.
Published Version
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