Abstract
Intravenous iron infusion may be complicated by extravasation and lead to cutaneous pigmentation. We queried the French pharmacovigilance database to assess the spontaneously reported cases over the 2000-2016period. Fifty-one cases of cutaneous pigmentation related to intravenous iron extravasation were retrieved, none was associated to necrosis. Most of patients were women aged 20to 49years old. The pigmentation was mostly a brown coloration, persisting over one month in 19cases (37.2%) and over 6months in 9cases (17.6%). The management of extravasation and pigmentation was heterogeneous and was rarely followed by a decrease of the coloration. Cutaneous pigmentation after intravenous iron extravasation can persist over time and create an aesthetic prejudice, particularly in young women. Standardized extravasation and iron-induced pigmentation management procedures appear necessary.
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