Abstract
Comprehensive SummaryVicinal all‐carbon quaternary stereocenters are widely present in natural products and bioactive molecules. However, the construction of such motif in one step from readily available starting materials remains a significant challenge. Herein, we report a phosphine‐catalyzed divergent γ,γ‐ and ε,γ‐umpolung domino addition of bisoxindoles with allenoates. This method serves as a practical tool for the concise synthesis of a series of bisoxindole derivatives bearing sterically hindered vicinal all‐carbon quaternary stereocenters under mild reaction conditions. The applicability of this novel method was demonstrated with the gram‐scale synthesis of three known advanced intermediates for the total syntheses of calycanthine, chimonanthine and folicanthine.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call