Abstract
Comprehensive SummaryA novel carboanion relay enabled [1 + 2 + 2 + 1] cascade cyclization reaction utilizing rarely used isatin‐derived β‐silylcarbinols and aryl methyl ketones as readily available starting materials has been developed, endowing a powerful platform for the streamline synthesis of cyclohexane‐tethered bispirooxindoles in decent yields with high diastereoselectivities. This protocol was realized by merging triple Michael additions and C—C bond cleavage using Cs2CO3 as a robust promotor under transition metal‐free conditions. The practicability of this method is demonstrated by its simple operation, broad substrate scope as well as easy scale‐up.
Published Version
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