Abstract
Effects of two widely used industrial solvents-toluene and trichloroethyleneon liver and kidney function have been studied in laboratory rats after microsomal induction with phenobarbital. Higher efflux of GOT and GPT suggests that phenobarbital pretreatment stimulates hepatic toxicity of toluene in rats. However, a decline in GPT was recorded in phenobarbital- and trichloroethylenetreated rats. Further, observations on alkaline phosphatase suggest that the metabolic disposition of toluene and trichloroethylene is altered by pretreatment with phenobarbital. Phenobarbital potentiates the necrotizing damage caused by toluene; however, it offers protection against cholestatic injury. In trichloroethylene-treated rats as well, only partial protection could be offered by phenobarbital. Pretreatment of rats with phenobarbital results in a noticeable stim ulation of hepatic cytochrome P450s that are responsible for the metabolism of various drugs and xenobiotics. However, responses are typified by the multiple f...
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