Abstract
Abstract Experiments were undertaken to examine the role of various endocrine factors (adrenal, pancreas, and testis) on daily (24h) variations in hepatic microsomal drug metabolism.Adrenalectomy and alloxan‐induced diabetes abolished the daily variation in drug metabolism as well as producing alterations in the basal levels of hepatic microsomal enzyme activity. Castration and insulin treatment abolished only the daily variation in ethylmorphine metabolism. These data suggest that various endocrine factors influence basal levels of hepatic drug metabolism; however, daily variations in hepatic drug metabolism are apparently not causally related to similar variations in plasma hormone levels.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
