Abstract
Basic research in the biomedical field works with models from the subcellular up to the organism level, with demands to translate them into the human situation. Starting from subcellular systems and ending with animal models, scientist are confronted with increasing complexity hampering the interpretation of their results (1). Therefore, it is important to recognise the differences between the experimental models and the situation in human to design and evaluate the test system accordingly. For testing of drugs, drug candidates as well as toxic substances, the animal model is still an indispensable and frequently used intermediate step (2-4). Its relevance has been shown in simulations of cardiovascular diseases (5, 6), diabetes (7, 8) or kidney diseases (9, 10).
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