Abstract
Oxytetracycline (OTC) is a tetracycline broad-specturm antibiotic with bacteriostatic action. The pharmacokinetic properties and the residue level of OTC were studied after dipping to cultured rock fish, (283±5 g) Sebastes schlegelii. For pharmacokinetic studies, OTC of 50, 100 and 400ppm were administered at 15±1℃ and OTC concentrations were determined in plasma, muscle and liver by HPLC-DAD. Plasma, muscle and liver samples were taken at 0.5, 1, 3, 6, 12, 24, 48, 168 and 336h post-injection. The kinetic profiles of OTC were analyzed by fitting to a two-compartmental model. The kinetic profile of the OTC was found to be dose dependent. The time for maximum concentration (TSUBmax/SUB) and the maximum concentration (CSUBmax/SUB) of 400ppm OTC were 2.12h at 1.66㎍/㎖ in plasma, 15.25h at 0.95㎍/㎖ in muscle, and 15.3h at 6.29㎍/㎖ in liver. The absorption half-life (tSUB1/2/SUBα) of 400ppm OTC was 1.24h in plasma, 9.43h in muscle, and 10.31h in liver, respectively, whereas the elimination half-life (tSUB1/2/SUBβ) of the drug was 90.28h in plasma, 265.3h in muscle, and 6.93 ×105h in liver. A higher OTC residue level of liver in comparison with muscle and plasma was showed at all time points
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