Abstract
The penetration of oxytetracycline (OTC) into the oral fluid and plasma of pigs and correlation between oral fluid and plasma were evaluated after a single intramuscular (i.m.) dose of 20mg/kg body weight of long-acting formulation. The OTC was detectable both in oral fluid and plasma from 1hr up to 21day after drug administration. The maximum concentrations (Cmax ) of drug with values of 4021±836ng/ml in oral fluid and 4447±735ng/ml in plasma were reached (Tmax ) at 2 and 1hr after drug administration respectively. The area under concentration-time curve (AUC), mean residence time (MRT) and the elimination half-life (t1/2β ) were, respectively, 75613 ng×hr/ml, 62.8hr and 117hr in oral fluid and 115314 ng×hr/ml, 31.4hr and 59.2hr in plasma. The OTC concentrations were remained higher in plasma for 48hr. After this time, OTC reached greater level in oral fluid. The strong correlation (r=.92) between oral fluid and plasma OTC concentrations was observed. Concentrations of OTC were within the therapeutic levels for most sensitive micro-organism in pigs (above MIC values) for 48hr after drug administration, both in the plasma and in oral fluid.
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