Abstract
ABSTRACT The effect of cumin (Cuminum cyminum Linn.) on tissue lipid peroxidation and antioxidants in experimental diabetes mellitus was evaluated. Albino rats, non-diabetic and diabetic [those injected with alloxan monohydrate (150 mg kg−1 body weight) intraperitoneally to induce diabetes mellitus, blood glucose in the range of 200–300 mg dl−1, were used in the study. Cumin (0.25 g kg−1 body weight in distilled water) was given to non-diabetic and diabetic rats everyday by intragastric incubation for six weeks. Significantly elevated levels of thiobarbituric acid reactive substances (TBARS) and conjugated dienes and significantly reduced levels of reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) were observed in the pancreas, liver, kidney, intestine and aorta of diabetic rats as compared with the non-diabetic rats. Administering cumin significantly decreased the levels of TBARS and conjugated dienes and elevated the levels of GSH, SOD, CAT, GPx and GST in the pancreas, liver, intestine and aorta of diabetic rats as compared with the non-diabetic rats. Our data indicate that supplementation with cumin can reduce free radical mediated oxidative stress to the cells in experimental diabetes mellitus.
Published Version
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