Abstract
In the production of virus vaccines, human diploid cells are more advantageous over primary cells in terms of avoiding exogenous contamination, poor stability, and inconsistent antigenicity. Diploid cells can also be used to build cell seed bank system and are more suitable for quality control. Human diploid cell strains currently commonly used as cell matrix include MRC-5, 2BS, KMB-17, WI-38, and SV-1. This review summarizes the requirements and quality evaluation of human diploid cell strains from domestic and foreign laws and regulations to promote the construction and application of human diploid cell strains. Key words: Viral vaccines; Human diploid cells; Application
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