Application of human diploid cell strains 2BS and KMB17 in vaccine research

Abstract

Human diploid cells are the cell matrix for safer vaccine production approved by WHO, and have become the first choice for vaccine production in the world. The diploid 2BS and KMB17 strains independently developed in China are derived from human embryonic lung cells. Because they have no carcinogenicity, no xenobiotic pollutants and relatively stable cell characteristics, they are used more and more often in human vaccine development and production. Since 2BS and KMB17 cells are sensitive to a variety of viruses, they have also been used as cell substrates in the development of many viral vaccines. The vaccines produced by these two kinds of human diploid cells have been widely marketed in China, including hepatitis A vaccine, poliovirus vaccine, and inactivated enterovirus 71 vaccine. Key words: Human diploid cells; Research; Vaccines; Viruses