Abstract
Objective To study on the immunogenicity of inactived hepatitis A vaccine in cynomolgus macaques.Methods The SH strain of hepatitis A virus was cultured in human embryo lung diploid cell (MRC-5) to harvest virus bulk,which was absorbed with alum adjuvant to prepare inactived hepatitis A vaccine after purification and inactivation.Then the study on the immunogenicity of vaccine was carried out on cynomolgus macaques.Results Specific anti-HAV antibodies and neutralizing antibodies were induced in cynomolgus macaques after immunization,while the test result of antinuclear antibodies appeared negative.Conclusion The inactivated hepatitis A vaccine prepared with SH strain showed high safety and good immunogenicity. Key words: Inactived hepatitis A vaccine; Cynomolgus macaques; Immunogenicity
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