Abstract
The expression of HL-A antigens was found to remain unchanged throughout the finite in vitro lifetime of three human embryonic diploid cell strains (WI-38, WI-26 and MRC-5) and twelve adult skin fibroblast cultures. It is unlikely, therefore, that any immunological theory of senescence would be tenable if it depends on in vitro changes in HL-A specificities with age. One practical result of this finding is the possibility of distinguishing between human diploid cell populations derived from normal individuals of the same sex.
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