Abstract
Summary. Impulse oscillometry (IOS) is a non-invasive method for the functional assessment of respiratory dis-orders that does not require active participation from the patient during examination. Studies on the use of IOS in children with neuromuscular diseases (NMD), in-cluding neuromuscular spinal deformities, are limited.The aim of the study was to investigate the correlation between spirometry and impulse oscillometry parame-ters in children with NMD, including those with neuro-muscular scoliosis. Materials and methods: A retrospec-tive evaluation of spirometry and impulse oscillometry results was conducted in 56 children aged 5 to 17 years with neuromuscular diseases under medical observa-tion for at least 3 years. These children performed both functional studies correctly. Exclusion criteria included the presence of dyspnea of any etiology, the need for respiratory support, and the inability to communicate with the operator. IOS results were assessed considering the degree of deviation of spirometry indicators from the expected values. Results: In patients with myopa-thic NMD (Duchenne muscular dystrophy), a statistical-ly significant negative correlation was found between vital capacity (VC), forced VC (FVC), peak cough flow (PCF), and airway resistance indices (high correlation according to Cheddock’s scale, p<0.001), with no cor-relation between FEV1 indices and impulse oscillome-try. No statistically significant correlations were found in the group of patients with neuromuscular scoliosis.Conclusion: In patients with Duchenne muscular dystro-phy, the negative correlation between spirometry and impulse oscillometry indicators suggests an increase in airway resistance as lung volumes decrease, which can be used for early diagnosis and dynamic assessment of respiratory impairment progression. In patients with neuromuscular scoliosis, no correlation between spirom-etry and impulse oscillometry indicators was established
Published Version
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